And some patients developed autoimmune thyroid disease, a treatable condition. Side effects of HSCT can include infertility, said Burt, who noted that women can choose to preserve their eggs before treatment. And the proportion of patients with no evidence of disease was (about) 40% at six months, 21% at one year and 3% by years four and five. Living with multiple sclerosis means struggles and triumphsīy contrast, almost one quarter of the patients in the disease-modifying therapy group showed disease progression at one year, more than half at two years, and just under three-quarters at five years. Meanwhile, the proportion of patients with no evidence of disease – defined as no progression, no relapses, and no new or enlarging lesions on MRI scans – was (nearly) 98% at one year, 93% at two years, 90% at three years, and 78% at four and five years.Ĭarol Sadrozinske's three sons have brought her tremendous joy while fighting multiple sclerosis. ![]() Disease progression was measured using the Expanded Disability Status Scale, a method for monitoring changes in symptoms over time.Īmong the HSCT group, the proportion of patients with disease progression was (roughly) 2% up to two years, 5% at three years, and 10% at 4 and 5 years. Yet, 34 of 55 patients in the disease-modifying therapy group showed disease progression at one year. HSCT proved to be the more effective treatment: Of 55 patients receiving HSCT, only three patients showed disease progression at one year, the study showed. ![]() Patients received either the HSCT protocol or a different class of disease-modifying therapy than they’d previously used. The new comparison study took place at medical centers in the US, UK, Sweden and Brazil, where 110 patients with relapsing-remitting MS participated in the randomized clinical trial, a gold standard medical test. These are a dozen or more drugs designed to be chronic, continuous treatment that targets and modulates the immune system. ![]() In contrast, disease-modifying therapies work differently. New stem cell treatment 'halts' effects of multiple sclerosis Researchers say building a computer simulation could improve understanding and treatments of brain diseases like Alzheimer's.
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